Grant for Exploratory Research: Novel Methods for AttachingDNA to a Surface for STM and AFM Experiments

探索性研究资助：将 DNA 附着到 STM 和 AFM 实验表面的新方法

• 批准号: 9206802
• 负责人: Thomas Beebe
• 金额: $ 4万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-15 至 1993-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9206802&HistoricalAwards=false
• 关键词: Grant; Exploratory; Research; Novel; Methods

This research project in the Analytical and Surface Chemistry Program has been funded as a Small Grant for Exploratory Research. The research will develop two novel methods for attaching DNA and other biomolecules to substrates for their subsequent examination by scanning probe microscopy. Successful implementation of these attachment methods will allow the full power of scanning tunneling and atomic force microscopy to be applied to the structural characterization of biomolecules and other macromolecular systems. Such structural information is essential to understanding the mechanisms of biomolecule reactions and their relation to life processes. %%% The ability to anchor a large biomolecule to a substrate for microscopic examination will be developed in this research project. The interaction of scanning microscopy probes with the molecule under study has limited the applicability of these powerful methods for large molecules. This research project promises to address these limitations, resulting in a better understanding of the structure of these biologically important molecules.

该分析和表面化学计划中的研究项目已被资助为探索性研究的小型赠款。 这项研究将开发两种新的方法，将DNA和其他生物分子连接到底物上，以通过扫描探针显微镜检查其后续检查。 这些附着方法的成功实施将允许将扫描隧道和原子力显微镜的全部功能应用于生物分子和其他大分子系统的结构表征。 这种结构信息对于理解生物分子反应的机制及其与生命过程的关系至关重要。 %%％将在该研究项目中开发出大量生物分子以进行微观检查的基板。 扫描显微镜探针与所研究分子的相互作用限制了这些强大方法对大分子的适用性。 该研究项目有望解决这些局限性，从而更好地理解了这些生物学上重要的分子的结构。