Establishing Essential Research Tools to Advance the Knowledge of Interrelated Sex Differences in Adipose and Immune Functions in Health and Disease (The SDAI Core Models) and Exploring the Mechanisms Involved in the Sex-dimorphic Role of Prohibitin Above

建立必要的研究工具，以增进对健康和疾病中脂肪和免疫功能相关性别差异的了解（SDAI核心模型），并探索上述抑制素的性别二态性作用所涉及的机制

• 批准号: 438069
• 负责人: Mishra Suresh
• 金额: $ 7.29万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-10-01 至 2021-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=438069&lang=en
• 关键词: Gonadectomy; Hormone Replacement Therapy; Metabolic Dysregulation; Prohibitin; Puberty; Sex Differences In Adipocyte Functions; Sex Differences In Immune Functions; Sex Steroids; Ttransgenic, Knockout, And Knock-In Mice; X-Linked Genes

Fat cell and immune cell functions undergo parallel changes in the body during various stages of life in health and disease. The most notable examples are puberty, pregnancy, and menopause, as well as metabolic and immune diseases. Notably, both cell type

在健康和疾病的生命各个阶段，脂肪细胞和免疫细胞功能在体内经历平行变化。最显着的例子是青春期、怀孕和更年期，以及代谢和免疫疾病。值得注意的是，两种细胞类型