Identifying how cortical bone microstructure deteriorates with age

确定皮质骨微观结构如何随着年龄的增长而恶化

• 批准号: DP230100135
• 负责人: Prof Natalie Sims
• 金额: $ 42.12万
• 依托单位: Australian Catholic University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100135
• 关键词: Identifying; how; cortical; bone; microstructure

This project aims to define the disruptions responsible for the gradual weakening of the skeleton in ageing by integrating a range of high-resolution imaging, biomechanical, and computational methods. The expected significance of this project includes a full definition and comparison of the cellular and subcellular organisation of bone from young and elderly individuals. Expected outcomes of this international project include the establishment of a new multidisciplinary research team, and the development of a new data-driven theoretical framework for understanding the nature and the causes of age-related bone fragility. Potential long-term benefits include new ways to treat age-related osteoporosis.

该项目旨在通过整合一系列高分辨率成像，生物力学和计算方法来定义负责老化骨骼逐渐减弱的破坏。该项目的预期意义包括对年轻人和老年人的骨骼细胞和亚细胞组织的完整定义和比较。该国际项目的预期结果包括建立一个新的多学科研究团队，以及开发一个新的数据驱动的理论框架，以理解与年龄相关的骨骼脆弱性的性质和原因。潜在的长期益处包括治疗与年龄相关的骨质疏松症的新方法。