Alkoxycyclopropyl and Cyclobutylphosphonium Salts: Preparation and Reaction in a Tandem Ring Expansion Wittig Reaction

烷氧基环丙基和环丁基鏻盐：串联扩环 Wittig 反应中的制备和反应

• 批准号: 9113059
• 负责人: Suzanne Ruder
• 金额: $ 1.8万
• 依托单位: Virginia Commonwealth University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-15 至 1993-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9113059&HistoricalAwards=false
• 关键词: Alkoxycyclopropyl; Cyclobutylphosphonium; Salts; Preparation; Reaction

This project involves the formation of strained rings containing both alkoxy and arylphosphonium salt functional groups so that their utility in a tandem ring expansion-Wittig reaction can be assessed. The alkoxycyclopropyl and cyclobutyl phosphonium salts will be prepared from beta-oxophosphonium salt derivatives. Formation of these substituted strained rings has not been reported, so an efficient method leading to their synthesis is of clear value. In addition, their preparation will lend new insights into the reactivity and applications of the beta-oxophosphonium salts, which are themselves important Witting reaction precursors. Finally, the study of the ring cleavage of these strained rings followed by a subsequent Witting reaction will determine whether this method will be suitable for development in more complex systems. %%% Research Planning Grants enable women who have not had prior independent Federal research support to develop a competitive research proposal. This project involves organic chemical reactions leading to medium-sized rings which are common in a large number of natural products.

该项目涉及形成含有烷氧基和芳基磷酸盐官能团的紧张环，以便可以评估它们在串联环扩展中的效用。 烷氧基丙基和环丁基磷酸盐将从β-氧磷酸盐衍生物制备。 尚未报道这些取代的紧张环的形成，因此导致其合成的有效方法具有明显的价值。 此外，他们的制备将为β-氧磷磷盐的反应性和应用提供新的见解，这些盐本身就是重要的反应前体。 最后，对这些紧张的环的环裂解，然后进行随后的动力反应的研究将决定该方法是否适合在更复杂的系统中开发。 %%％％研究计划授予，使没有事先独立联邦研究支持的妇女能够制定竞争性研究建议。 该项目涉及导致中型环的有机化学反应，这些反应在大量天然产品中很常见。