Synthetic Studies in the Field of Natural Product Chemistry

天然产物化学领域的合成研究

• 批准号: 8909762
• 负责人: Yoshito Kishi
• 金额: $ 87.38万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-01 至 1994-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8909762&HistoricalAwards=false
• 关键词: Synthetic; Studies; Field; Natural; Product

The Synthetic Organic Program supports the work of Yoshito Kishi. Kishi, Professor of Chemistry at Harvard University, is involved with a broadly based program of natural products chemistry. Included is a continuation of work on the synthesis of palytoxin, one of the most complicated organic compounds known. As a consequence of these efforts, new approaches to examine the shapes of complex molecules, and answers to fundamental questions about factors controlling the shapes of sugars are being developed. New methods for understanding the phenomena of bioluminescence and syntheses of compounds responsible for natural bioluminescence are also being undertaken. The major objective of this work is to make significant contributions to organic chemistry through investigations into eight research topics including: the total synthesis of palytoxin, the local conformational analysis of palytoxin, the conformational analysis of C- and O- glycosides, preparation and chemistry of helical oligopeptides, bioluminescence chemistry of dinoflagellate and krill systems and the bioluminescence of mushroom systems.

合成有机计划支持Yoshito Kishi的工作。 哈佛大学化学教授基希（Kishi）参与了一项广泛的天然产品化学计划。 其中包括延续合成palytoxin（已知最复杂的有机化合物之一）的作品。 这些努力的结果是，正在开发有关控制糖形状的因素的基本问题的新方法，以及对基本问题的答案。 还正在进行了解生物发光现象和负责自然发光的化合物的合成现象的新方法。 这项工作的主要目的是通过研究八个研究主题，包括：巴毒素的总合成，质量毒素的局部构象分析，c-和o-糖苷的构象分析，制备和化学的构象分析，制剂的构象分析，螺旋寡肽，鞭毛和磷虾系统的生物发光化学以及蘑菇系统的生物发光。