Alpha1-Adrenergic Receptor Subtypes in SmoothMuscle

SmoothMuscle 中的 Alpha1 肾上腺素受体亚型

• 批准号: 8908074
• 负责人: Kenneth Minneman
• 金额: $ 25.85万
• 依托单位: Emory University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-11-15 至 1992-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8908074&HistoricalAwards=false
• 关键词: Alpha1; Adrenergic; Receptor; Subtypes; SmoothMuscle

This is a project to examine some of the processes by which blood pressure is regulated. Normally, the brain sends messages to arteries and veins through nerves. Activation of these nerves causes the blood vessels to contract by releasing a chemical messenger, norepinephrine. The receptor molecules for norepinephrine which are on the surface of the muscle cells in the blood vessels will be studied. Dr. Minneman has previously shown that there are several different types of such receptors, which are affected differently by various drugs. He will now study the molecular mechanisms by which these different receptor types cause the blood vessels to contract. He is particularly interested in whether these receptors are acting through different mechanisms to cause contraction, as is suggested by preliminary results. Identification of these different mechanisms will be important in understanding more about how blood pressure is regulated, and in helping to identify ways to selectively control blood pressure. //

这是一个研究调节血压的一些过程。 通常，大脑通过神经向动脉和静脉发送信息。 这些神经的激活导致血管通过释放化学信使去甲肾上腺素来收缩。 将研究在血管中肌肉细胞表面的去甲肾上腺素的受体分子。 Minneman博士先前已经表明，有几种不同类型的受体受到各种药物的影响不同。 现在，他将研究这些不同受体类型导致血管收缩的分子机制。 正如初步结果所暗示的那样，他对这些受体是否通过不同的机制作用特别感兴趣。 这些不同机制的识别对于更多地了解如何调节血压以及帮助确定选择性控制血压的方法将很重要。 //