New Metal Catalyzed Organic Transformations

新金属催化有机转化

• 批准号: 8903218
• 负责人: K. Barry Sharpless
• 金额: --
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 1992-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8903218&HistoricalAwards=false
• 关键词: New; Metal; Catalyzed; Organic; Transformations

The Organic Synthesis Program supports the work of Dr. K. Barry Sharpless. Sharpless, Prof. of Chemistry at MIT, continues his pioneering investigations of new reagents for organic synthesis. His current work is, in part, directed towards examining how metals complex to existing groups in a molecule to direct new reactions to a particular site. Notable new directions include trying to develop methods that do not require an existing tether to direct the chemistry. Sharpless's group continues to investigate the mechanistic details of ligand-accelerated catalysis of reactions, and how this leads to the remarkable enantioselectivity observed for the reactions. As part of his mechanistic investigations he has recently discovered a process for dihydroxylating an isolated alkene bond without prior binding of the reagent to the substrate. This discovery opens a whole new arena for scientific enquiry, and has great potential for synthetic chemists. His group is trying to also understand the origins of this process. Sharpless will "comb the periodic table" looking for new reagents to add to the arsenal already available to the synthesis chemist. Initial scrutiny will be given to finding unique metal/ hydroperoxide combinations to carry out asymmetric epoxidation to isolated alkenes. A unique assay system, analgous to that used for screening for bioactivity of molecules, will be employed to examine large series of reactions.

有机合成计划支持K. Barry Sharpless博士的工作。 麻省理工学院化学教授Sharpless继续对有机合成的新试剂进行开创性研究。 他目前的工作部分是针对研究分子中现有组的金属如何将新反应引导到特定位点的。 值得注意的新方向包括尝试开发不需要现有系绳来指导化学反应的方法。 Sharpless的小组继续研究配体加速反应催化的机理细节，以及这如何导致反应观察到的显着对映选择性。作为他的机械研究的一部分，他最近发现了一个二氢氧化的过程，而没有试剂与底物的事先结合，而没有事先结合。 这一发现为科学探究开辟了一个全新的领域，并具有合成化学家的巨大潜力。 他的小组正试图了解这一过程的起源。 Sharpless将“梳理元素周期表”，以寻找新的试剂，以添加到已成合成化学家的阿森纳。 最初的审查将对找到独特的金属/氢过氧组合进行对分离的烷烃进行不对称的环氧化。 将采用与用于筛选分子生物活性的独特测定系统，用于检查大量反应。