U.S.-Brazil Cooperative Research on Seven-Membered Rings ViaNitrenium Ions

美国-巴西通过氮离子合作研究七元环

基本信息

批准号：
8902803
负责人：
Rudolph Abramovitch
金额：
$ 1.54万
依托单位：
Clemson University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
1989
资助国家：
美国
起止时间：
1989-10-01 至 1993-03-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=8902803&HistoricalAwards=false
关键词：
U.S.Brazil Cooperative Research Seven

项目摘要

This award supports cooperative research in the chemistry of carbon-bond seven-membered ring formation to be carried out by Rudolph Abramovitch of Clemson University and J.A.R. Rodriguez of the University of Campinas in Brazil. A new method of formation of seven-membered rings, previously discovered by the collaborators, will be extended to the production of homo- and hetero-cyclic rings to determine the structural and geometrical factors which favor ring formation. Then, convenient routes to molecules related to naturally-occurring anticancer agents will be examined. This will lead to the preparation of a variety of derivatives which retain useful biological activity but with reduced toxicity. The objective is to develop mild, useful routes to desirable biologically active compounds. This work is a continuation of a productive cooperation between the group at Campinas, a former member of which is now at Sao Paulo establishing a graduate program with eighteen research students, and Dr. Abramovitch's group at Clemson. The Brazilian P.I. and a student have both spent time at Clemson which has helped in the establishment of a small research group at Campinas now working on arylnitrenium ion chemistry. This study will increase the knowledge of the formation, structure and reactivity of arylnitrenium and -oxenium ions and bond formation in seven-membered rings which occur widely in nature and have been the target of much scientific and medicinal attention.

该奖项支持Clemson University的Rudolph Abramovitch和J.A.R.进行的碳键七元环形成化学研究。巴西Campinas大学的Rodriguez。以前由合作者发现的七元环形成的新方法将扩展到同型和异偶带环的生产，以确定有利于环形成的结构和几何因素。然后，将检查与与天然抗癌药有关的分子方便路线。这将导致制备各种衍生物，这些衍生物保留了有用的生物学活性但毒性降低。目的是为理想的生物活性化合物开发温和的有用途径。这项工作是该小组在Campinas之间进行了富有成效的合作的延续。巴西P.I.一名学生都在克莱姆森（Clemson）度过了一段时间，这帮助在坎皮纳斯（Campinas）建立了一个小型研究小组，目前正在从事芳基硝酸化学化学。这项研究将提高人们对七元环中芳基硝法和 - 氧化离子的形成，结构和反应性以及在自然界广泛发生的七元环中形成的知识，并且已经成为广泛的科学和药物关注的目标。