Cooperative Research on Photoaffinic Labelling of Compounds with Pyrene

芘化合物光亲和标记合作研究

• 批准号: 8814467
• 负责人: J. Kerry Thomas
• 金额: $ 1.18万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-03-15 至 1991-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8814467&HistoricalAwards=false
• 关键词: Cooperative; Research; Photoaffinic; Labelling; Compounds

This award supports cooperative research in photochemistry between J. Kerry Thomas of Notre Dame University and Andres Olea of the University of Chile in Santiago. The work will involve the photolabelling of organic (biological) compounds with pyrene. Such photoreactions have been studied at both universities with this specific work having its start at Notre Dame. The approach will include the location of the pyrene, whether in the choline region, or close to the glycerol or to the alkane chain region and also the production of derivatives of pyrene for probing other systems such as micelles, vesicles, simple alkanes and polyelectrolytes. Techniques already in use are fast pulse kinetics at Notre Dame and steady state kinetics in Chile. These will complement each other to establish the mechanisms by which the probe molecules: pyrene, azopyrene and azidopyrene form the addition products with the host medium. Chile's strength is in product analysis and that of Notre Dame is in fast pulse analysis of earlier events. This cooperation will lead to the development of photochemical mechanisms of great use to the photochemical and colloid community.

该奖项支持巴黎圣母院大学的J. Kerry Thomas与圣地亚哥大学的Andres Olea之间的光化学合作研究。 这项工作将涉及有机（生物）化合物与pyrene的光标记。 这两种特定的工作都在巴黎圣母院开始研究。 该方法将包括吡啶的位置，无论是在胆碱区域，还是靠近甘油或烷烃链区域，以及pyrene的衍生物的产生，用于探测其他系统，例如胶束，囊泡，简单的烷烃和聚电解质。 在巴黎圣母院的快速脉冲动力学和智利的稳态动力学是快速的脉冲动力学。 这些将互相补充以建立探针分子的机制：pyrene，苯二吡啶和氮杂吡啶与宿主培养基形成添加产物。 智利的强度在于产品分析，巴黎圣母院的强度是对早期事件的快速脉冲分析。 这种合作将导致对光化学和胶体社区的光化学机制的发展。