Investigating the cross-talk between the aryl hydrocarbon receptor and estrogen receptor alpha

研究芳烃受体和雌激素受体α之间的串扰

• 批准号: 184437
• 负责人: Ahmed Shaimaa
• 金额: $ 7.65万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-10-01 至 2011-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=184437&lang=en
• 关键词: Aryl Hydrocarbon Receptor; Cancer; Cell Culture; Chromatin Immunoprecipitation; Estrogen Receptor Alpha; Gene Expression; Microarray; Molecular Biology; Sirna; Western Analysis

Estrogens are involved in many physiological processes such as reproduction, behaviour and development. Estrogen mediates these effects by binding to estrogen receptor alpha (ERalpha). It has been shown that improper activation of ERalpha by estrogen is t

雌激素参与许多生理过程，例如生殖、行为和发育。雌激素通过与雌激素受体α（ERα）结合来介导这些作用。研究表明，雌激素对 ERα 的不当激活会导致雌激素的过度激活。