Characterising a novel stress-sensing signalling factor

表征新型压力感应信号因子

• 批准号: DP230102652
• 负责人: A/Prof Benjamin Parker
• 金额: $ 51.25万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-17 至 2026-01-16
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102652
• 关键词: Characterising; novel; stress; sensing; signalling

Aim: To understand how phosphorylation regulates signalling pathways to allow metabolic adaptations in response to energetic stress. Significance: A fundamental understanding of the activation of signalling pathways via phosphorylation is vital for our knowledge of homeostasis and the mechanisms controlling cell survival. Expected outcomes: To generate new systems biology and physiology data to understand how the stress response is regulated and characterise new stress-sensing pathways. Benefits: A greater understanding of the molecular mechanisms controlling metabolism in response to stress has extremely broad applications to improve metabolic efficiency in fields ranging from exercise- and life-sciences to agriculture.

目的：了解磷酸化如何调节信号通路，从而实现代谢适应以应对能量应激。意义：对通过磷酸化激活信号通路的基本了解对于我们了解体内平衡和控制细胞存活的机制至关重要。预期成果：生成新的系统生物学和生理学数据，以了解如何调节应激反应并表征新的应激感知途径。好处：更好地了解控制新陈代谢以应对压力的分子机制对于提高从运动和生命科学到农业等领域的代谢效率具有极其广泛的应用。