Protection against apoptosis in presbycusis and noise/drug induced hearing loss by cochlear transfection of xiap gene in experimental animals

实验动物耳蜗转染xiap基因可预防老年性耳聋和噪音/药物引起的听力损失

• 批准号: 171095
• 负责人: Wang Jian
• 金额: $ 37.51万
• 依托单位: Dalhousie University (Nova Scotia)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-09-01 至 2012-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=171095&lang=en
• 关键词: Apoptosis; Cochlear Gene Transfection; Noise; Ototoxicity; Presbycusis/Aging; Xiap

The receptor cells (the hair cells) and neurons in mammalian ears degenerate with aging. This degeneration is enhanced by damaging factors such as noise and ototoxic drugs. Hair cell death due to aging and many other factors occurs mainly through a proces

哺乳动物耳朵中的受体细胞（毛细胞）和神经元会随着衰老而退化。这种退化会因噪音和耳毒性药物等破坏性因素而加剧。由于衰老和许多其他因素导致的毛细胞死亡主要通过一个过程发生