Crystallographic Studies on Heme Containing Enzymes

含血红素酶的晶体学研究

• 批准号: 8716316
• 负责人: Thomas Poulos
• 金额: $ 23.82万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-05-01 至 1991-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8716316&HistoricalAwards=false
• 关键词: Crystallographic; Studies; Heme; Containing; Enzymes

Three basic classes of heme containing enzymes, peroxidases, oxygenases and oxidases, each play a critical role in a number of biological processes. As with any class of enzyme, a thorough understanding of structure-function relationships is not possible without crystallographic information. To date the crystal structure of only three heme-containing enzymes are known. Dr. Poulos plans to build on what he has learned from the determination of the cytochrome c peroxidase, catalase and cytochrome P450 structures. He will explore in greater depth the structure-function relationship in these enzymes. The study will contribute to the body of understanding of electron transfer processes and heme-enzyme function.***//

含有酶，过氧化物酶，氧化酶和氧化酶的三种基本类别的血红素类别在许多生物过程中起着至关重要的作用。 与任何类别的酶一样，如果没有晶体学信息，对结构 - 功能关系的透彻关系是不可能的。 迄今为止，仅知道三种含血红素的酶的晶体结构。 Poulos博士计划基于他从细胞色素C过氧化物酶，过氧化氢酶和细胞色素P450结构的确定中学到的知识。 他将在这些酶中更深入地探索结构功能关系。 这项研究将有助于对电子转移过程和血红素酶功能的理解。*** //