Structure/Function Analysis of Cut Repeat Domains in Base Excision Repair

碱基切除修复中切割重复结构域的结构/功能分析

• 批准号: 306567
• 负责人: Nepveu Alain
• 金额: $ 44.07万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-03-01 至 2019-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=306567&lang=en
• 关键词: Abasic; Alkylated Bases; Apurinic; Apurinic/Apyrimidic Endonuclease 1 (Ape1); Apyrimidic Sites; Base Excision Repair; Cut Repeats; Dna Glycosylases; Oxidized Bases (8-Oxoguanine)

Our genome is organized into long pieces of DNA, called chromosomes. Cancer is caused by the accumulation of changes in DNA (mutations) that result in the activation of "oncogenes" and the inactivation of "tumor suppressors". Some changes involve one or a

我们的基因组被组织成长的 DNA 片段，称为染色体。癌症是由 DNA 变化（突变）累积导致“癌基因”激活和“肿瘤抑制因子”失活而引起的。有些变化涉及一个或一个