CCN2 action in fibrosis: Cellular and molecular mechanisms

CCN2 在纤维化中的作用：细胞和分子机制

• 批准号: 303277
• 负责人: Leask Andrew C
• 金额: $ 57.17万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-03-01 至 2019-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=303277&lang=en
• 关键词: Adhesive Signaling; Ccn Family; Ccn1; Ccn2; Connective Tissue; Ctgf; Fibrosis; Matricellular Proteins

Fibrotic diseases including scleroderma (systemic sclerosis) are characterized by excessive scarring resulting in organ failure and amounts to ~45% of the deaths and health care costs in the developed world. There is no treatment for this diseases as the

包括硬皮病（系统性硬化症）在内的纤维化疾病的特点是过度疤痕形成，导致器官衰竭，约占发达国家死亡和医疗费用的 45%。这种疾病没有治疗方法，因为