Discovering how age-associated increases in pro-inflammatory cytokines contribute to impaired macrophage function & increased susceptibility to disease.

发现与年龄相关的促炎细胞因子的增加如何导致巨噬细胞功能受损

• 批准号: 311939
• 负责人: Naidoo Aveshni
• 金额: $ 1.27万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-12-01 至 2014-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=311939&lang=en
• 关键词: Chronic Inflammation; Disease In Elderly; Disease Susceptibility; Immunosenescence; Inflammaging; Macrophages; Microbial Translocation; Myeloid Skewing; Pro-Inflammatory; Tumor Necrosis Factor Alpha

Aging is accompanied by increased levels of protein mediators, known as cytokines, in serum and tissues, and observable changes in immune cell phenotype and function. This “inflammaging” is believed to contribute to a wide spectrum of diseases associated

衰老是血清和组织中称为细胞因子的核心介质，可观察到的免疫和功能变化。