NOVEL MASS-SCALE BIOSYNTHESIS: TAILORING CHEMICAL LOGIC & BIOSYNTHESIS

新颖的大规模生物合成：定制化学逻辑

• 批准号: IM230100534
• 负责人: A/Prof Tony Velkov
• 金额: $ 60.23万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Mid-Career Industry Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/IM230100534
• 关键词: NOVEL; MASS; SCALE; BIOSYNTHESIS; TAILORING

No new antibiotics against Gram-negative ‘superbugs’ are expected to be available in the near future. We have exhausted the chemical space from the natural product pool and lack a fundamental understanding of antibiotics in nature, this is a major hurdle for antibiotic design targeting bacterial resistance. This proposal aims to engineer unique chemo-enzymatic platforms for the synthesis of new lipopeptide scaffolds which will significantly expand the chemical space available for novel antibiotic discovery. The development of these unique platforms will greatly expand our inventory of natural product antibiotics and will represent a major technological break-through for Australia's biotechnology and pharmaceutical manufacturing sectors.

没有新的反对革兰氏阴性型'对抗生素内生物的基本了解，这是一个主要的障碍福特尔·福特尔·福特尔·福特尔·福克斯（Fordle Fordle Fordle Fordle Fordne），该提案旨在设计出独特的化学剂量平台，以实现抗生素的基本库。脚手架威尔·威尔·威尔（Will Will Will Will Will Will Will Will Will）可用于新颖的天然产品抗生素，并将代表澳大利亚的生物技术和药品制造业的主要技术突破。