Characterizing missense TLS variants

表征错义 TLS 变体

• 批准号: 486482
• 负责人: Cozma Ecaterina
• 金额: $ 1.27万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486482&lang=en
• 关键词: Cancer Therapy; Dna Damage Repair; Genomic Instability; High-Throughput Mutagenesis; Rev1; Rev3; Synthetic Lethal; Translesion Synthesis; Cancer Therapy; Dna Damage Repair; Genomic Instability; High-Throughput Mutagenesis; Rev1; Rev3; Synthetic Lethal; Translesion Synthesis

Cancer cells acquire many mutations due to the high replication burden they face. Such mutations place cancer cells at a unique disadvantage when compared to healthy cells, which can be exploited by synthetic lethal therapies. A synthetic lethal (SL) rela

由于他们面临的高复制负担，癌细胞获得了许多突变。与健康细胞相比，这种突变使癌细胞处于独特的劣势，可以通过合成致命疗法来利用。合成致命（SL）Rela