Investigating genetic interactions between RNA-binding proteins relevant to neurodegenerative disease in C. elegans

研究与线虫神经退行性疾病相关的 RNA 结合蛋白之间的遗传相互作用

• 批准号: 466721
• 负责人: Premachandran Sharanja
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=466721&lang=en
• 关键词: Als; C. Elegans; Crispr-Cas9; Disease; Gene Expression; Genetics; Loss-Of-Function; Neurodegeneration; Post-Transcriptional Gene Regulation; Rna-Binding Proteins

RNA binding proteins (RBPs) are a highly conserved group of post-transcriptional regulators, involved in processes that include mRNA polyadenylation, alternative splicing, nuclear export, and translation. As such, mutated RBPs have emerged as key players

RNA 结合蛋白 (RBP) 是一组高度保守的转录后调节因子，参与 mRNA 多腺苷酸化、选择性剪接、核输出和翻译等过程。因此，突变的 RBP 已成为关键参与者