Investigation into RAS GTPase control of cell adhesion and proliferation through alternative downstream effectors

研究 RAS GTPase 通过替代下游效应器控制细胞粘附和增殖

• 批准号: 443419
• 负责人: Smith Matthew J
• 金额: $ 55.45万
• 依托单位: Institute for Research in Immunology and Cancer (Montreal, QC)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-04-01 至 2026-04-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=443419&lang=en
• 关键词: Adhesion; Afdn (Afadin); Cryo-Em; Effectors; Hippo; Metastasis; Ras; Rassf; Rewiring; Tumour Suppressors

Abnormal changes to the genetic material of various cell types in the human body can lead to cancer, or more specifically the uncontrolled proliferation of cells. When this occurs, the affected genes create proteins that cannot be turned off in a normal f

人体内各种细胞类型的遗传物质的异常变化可能导致癌症，或更具体地说是细胞不受控制的增殖。当这种情况发生时，受影响的基因会产生无法在正常情况下关闭的蛋白质。