Phenotypic analysis of a putative mouse model for 'STING-associated vasculopathy with onset in infancy' (SAVI): an autosomal dominant auto-inflammatory interferonopathy

“婴儿期发病的 STING 相关血管病”（SAVI）假定小鼠模型的表型分析：一种常染色体显性自身炎症干扰素病

• 批准号: 434025
• 负责人: Jirik Frank R
• 金额: $ 67.15万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=434025&lang=en
• 关键词: Acral Vasculopathy And Necrosis; Autosomal Dominant Interferonopathy; Conditional Gene Activation Via Cre-Loxp Technology; Intravital And X-Ray Microscopy; Mouse Model Of Human Savi; Stimulator Of Interferon Genes (Sting); Sting-Associated Vasculopathy Of

'STING-associated vasculopathy with onset in infancy' (SAVI) is a rare, but increasingly recognized, disease of children. Individuals with this condition have been reported in many countries, including Canada. The condition is due to mutations in a gene k

“婴儿期发病的刺痛相关血管病”(SAVI) 是一种罕见但越来越被认识的儿童疾病。包括加拿大在内的许多国家都报告有患有这种疾病的人。这种情况是由于基因 k 的突变造成的