Determining astrocyte-mediated defects to glutamatergic signalling and metabolism in Fragile X Syndrome

确定脆性 X 综合征中星形胶质细胞介导的谷氨酸信号传导和代谢缺陷

• 批准号: 429074
• 负责人: Surendran Vithushan
• 金额: $ 1.27万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-12-01 至 2020-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=429074&lang=en
• 关键词: Astrocytes; Dendritic Spines; Fragile X Mental Retardation Protein; Fragile X Syndrome; Glial Cells; Glutamate Signalling; Metabolic Imbalance; Mitochondria Function; Neuronal Circuits; Reactive Oxygen Species

"<strong>Introduction.</strong> Fragile X Syndrome (FXS), the leading heritable form of autism spectrum disorder (ASD), is a neurodevelopmental disorder caused by silencing of the fmr1 gene leading to the inhibition of fmr1 transcription, and the absence

“ <strong>引言。</strong>脆弱的X综合征（FXS），是自闭症谱系障碍（ASD）的主要可遗传形式，是由FMR1基因沉默引起的神经发育障碍