Targeting SMOC2-induced epithelial-to-mesenchymal transition inhibits senescence in mouse models of kidney fibrosis

靶向 SMOC2 诱导的上皮间质转化可抑制小鼠肾纤维化模型的衰老

• 批准号: 410483
• 负责人: Gerarduzzi Casimiro
• 金额: $ 53.78万
• 依托单位: Centre de recherche de l'Hôpital Maisonneuve-Rosemont (Montral)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-09-01 至 2024-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=410483&lang=en
• 关键词: Chronic Kidney Disease; Epithelial-To-Mesenchymal Transformation; Extracellular Matrix; Kidney Fibrosis; Kidney Regeneration; Kidney Repair; Matricellular Proteins; Senescence; Smoc2; Transgenic Mouse Models

Kidney disease is a major public health concern because it affects an estimated 8-16% of the worldwide population while current treatment options are insufficient. One of the major characteristics of any kidney disease is a sustained and excess healing re

肾脏疾病是一个主要的公共卫生问题，因为它影响着全球约 8-16% 的人口，而目前的治疗方案还不够。任何肾脏疾病的主要特征之一是持续且过度的愈合过程。