局部骨骼与系统器官的内分泌对话

The traditional concept holds that the skeleton is an inert organ that supports the body, protects the internal organs, and maintains the calcium - phosphorus balance in the body. In recent years, the concept of the skeleton has undergone a subversive change. The skeleton is actually an active endocrine organ and can have a close dialogue with systemic organs. In fact, the skeleton can act on systemic organs by secreting special hormones (such as osteocalcin, fibroblast growth factor 23, lipocalin 2, etc.), regulating muscle function, energy metabolism, cognitive function, and male reproduction, etc. In order to better understand the important functions of the skeleton as an endocrine organ, this article systematically elaborates on the mutual dialogue between the skeleton and organs such as muscles, the brain, the kidneys, the liver, the pancreas, and the gonads as well as the dialogue mechanisms, providing new targets for the treatment of systemic organ diseases.

传统的观念认为骨骼是支撑身体、保护内脏、维持体内钙-磷平衡的惰性器官.近几年来,骨骼的概念发生了颠覆性改变,骨骼其实是一种活跃的内分泌器官,可与系统器官进行密切对话.事实上,骨骼可通过分泌特殊的激素(骨钙素、成纤维细胞生长因子23、脂质运载蛋白2等)作用于系统器官,调节肌肉功能、能量代谢、认知功能和男性生殖等。为了更好地认识骨骼作为内分泌器官的重要功能,本文对骨骼与肌肉、脑、肾脏、肝脏、胰腺及生殖腺等器官之间的相互对话及其对话机制进行系统阐述,为治疗系统器官疾病提供新的靶点。