Risk factors for stroke recurrence in young patients with first-ever ischemic stroke: A meta-analysis.

At present, the incidence rate of ischemic stroke in young people is increasing yearly, and the age of onset is increasingly young. Therefore, primary and secondary prevention of ischemic stroke in young people, especially secondary prevention, is particularly crucial. We aimed to comprehensively evaluate risk factors for stroke recurrence in first-ever young ischemic stroke (YIS) patients. The meta-analysis was used to quantitatively analyze the research results on risk factors for stroke recurrence in first-ever YIS patients both domestically and internationally. Stata12.0 software was used for heterogeneity testing, publication bias analysis, sensitivity analysis, and the calculation of combined odds ratios and 95% confidence intervals. The odds ratio (OR) values of the relationship between hypertension and hyperlipidemia and recurrence of first-ever YIS were 1.54 (1.05-2.26) and 1.12 (1.00-1.25), respectively. The OR values of male sex, type 2 diabetes, smoking, drinking and YIS recurrence were 1.66 (0.98-2.79), 1.01 (0.64-1.59), 1.21 (0.83-1.76), and 1.28 (0.82-2.53), respectively. The relationship between male sex, type 2 diabetes, smoking, drinking and YIS recurrence was ambiguous. Hypertension and hyperlipidemia are important risk factors for stroke recurrence in first-ever YIS patients, and active intervention should be taken.

目前，青年人缺血性脑卒中的发病率逐年上升，发病年龄日益年轻化。因此，青年人缺血性脑卒中的一级和二级预防，尤其是二级预防，尤为关键。 我们旨在全面评估首次发生缺血性脑卒中的青年患者（YIS）卒中复发的危险因素。 采用荟萃分析对国内外首次发生YIS患者卒中复发危险因素的研究结果进行定量分析。使用Stata12.0软件进行异质性检验、发表偏倚分析、敏感性分析以及计算合并优势比和95%置信区间。 高血压和高血脂与首次发生YIS复发之间关系的优势比（OR）值分别为1.54（1.05 - 2.26）和1.12（1.00 - 1.25）。男性、2型糖尿病、吸烟、饮酒与YIS复发的OR值分别为1.66（0.98 - 2.79）、1.01（0.64 - 1.59）、1.21（0.83 - 1.76）和1.28（0.82 - 2.53）。男性、2型糖尿病、吸烟、饮酒与YIS复发之间的关系不明确。 高血压和高血脂是首次发生YIS患者卒中复发的重要危险因素，应积极进行干预。