长链非编码RNA在绝经后认知功能减退中的研究进展

Long non-coding RNAs (lncRNAs) are involved in the occurrence and development of various diseases and are closely related to neurodegenerative diseases, especially cognitive dysfunction. There is much evidence indicating that cognitive decline exists in women after menopause. At present, there is no direct research on lncRNAs in postmenopausal cognitive decline, but indirect evidence shows that estrogen is closely related to lncRNAs that affect nerve function. This article reviews the role of lncRNAs in the occurrence and development of postmenopausal cognitive decline.

长链非编码RNA参与多种疾病的发生发展过程,与神经系统退行性疾病尤其是认知功能障碍密切相关。较多证据表明女性绝经后存在认知功能减退。目前尚无关于lncRNA在绝经后认知功能减退中的直接研究,但间接证据表明雌激素与影响神经功能的lncRNA关系密切。文章就lncRNA在绝经后认知功能减退的发生发展中的作用展开综述。