基于中西医临床病证特点的慢性阻塞性肺疾病稳定期动物模型分析

This research is based on the clinical syndrome characteristics of traditional Chinese and Western medicine in the stable stage of chronic obstructive pulmonary disease. By referring to relevant domestic and foreign literature on animal models and combining with the clinical diagnosis standards of traditional Chinese and Western medicine, it evaluates and analyzes the advantages and disadvantages of existing animal models and their clinical consistency, and sorts out and summarizes the model evaluation methods. The research results show that the existing modeling methods for animal models in the stable stage of chronic obstructive pulmonary disease include the smoke exposure method and the comprehensive modeling method, which includes smoke exposure combined with lipopolysaccharide or protease or bacterial infection. The manifestation of the animal models on the clinical characteristics of traditional Chinese medicine is generally poor, and the consistency with Western medicine is higher than that with traditional Chinese medicine. There is a lack of research on models in the stable stage of chronic obstructive pulmonary disease and models combining disease and syndrome. Although the etiological factors or mechanisms similar to those of the affected population are used for modeling, there is still a gap from the actual clinical situation, and further research is needed to formulate quantitative standards for models in the stable stage of chronic obstructive pulmonary disease.

该研究立足于慢性阻塞性肺疾病稳定期的中西医临床病证特点,通过查阅国内外动物模型相关文献,结合中西医临床诊断标准,对现有动物模型的优缺点及临床吻合度进行评价分析,整理汇总模型评价方法。研究结果发现,现有慢性阻塞性肺疾病稳定期动物模型造模方法有烟雾暴露法、综合造模法,包括烟雾暴露联合脂多糖或蛋白酶或细菌感染,动物模型对中医临床特征的体现普遍欠佳,西医吻合度较中医吻合度高。慢性阻塞性肺疾病稳定期模型和病证结合模型研究匮乏,尽管应用类似人群发病的病因或机制进行造模,但与临床实际情况仍有差距,有待深入研究以制定慢性阻塞性肺疾病稳定期模型的量化标准。