Sesquiterpene coumarins from seeds of Ferula sinkiangensis

A new sesquiterpene coumarin with a novel sesquiterpene carbon framework, Sinkiangenorin D, and ten known sesquiterpene coumarins were isolated from the seeds of Ferule sinkiangensis. The structures of these compounds, including the relative stereochemistry, were elucidated on the basis of spectroscopic data. All of the isolated compounds were tested against the AGS, HeLa, and K562 human cancer cell lines and showed cytotoxic activities with 50% inhibitory concentration values between 12.7 and 226.6 mu M. (C) 2015 Elsevier B.V. All rights reserved.

从新疆阿魏（Ferule sinkiangensis）的种子中分离出一种具有新型倍半萜碳骨架的新倍半萜香豆素——新疆阿魏素D（Sinkiangenorin D）以及十种已知的倍半萜香豆素。基于光谱数据阐明了这些化合物的结构，包括相对立体化学。所有分离出的化合物都针对AGS、HeLa和K562人类癌细胞系进行了测试，结果显示出细胞毒活性，其半数抑制浓度值在12.7至226.6 μM之间。（C）2015爱思唯尔有限公司。保留所有权利。