NR2F6在肿瘤中的研究进展

Nuclear receptor subfamily 2, group F, member 6 (NR2F6) is a member of the orphan nuclear receptors. It is expressed in major tissues and organs of the human body and plays an important role in a variety of biological functions and the regulation of gene expression. In recent years, its relationship with tumorigenesis and development has received extensive attention. Studies have shown that the expression of NR2F6 is upregulated in a variety of tumors and has an obvious correlation with many cancers. In addition, the latest research shows that NR2F6 also has an important function in tumor immunity and is expected to become a new immunomodulatory target. This article reviews the relevant research on the function of NR2F6 and its role in tumors at home and abroad in recent years, in order to provide new ideas for tumor treatment.

核受体亚族2,F组第6号成员NR2F6(Nuclear receptor subfamily 2,group F,member 6)是孤核受体中的一员,在人体主要组织、器官中均有表达,对多种生物学功能和基因表达调控起着重要的作用。近年来其与肿瘤发生发展的关系受到广泛关注,研究表明, NR2F6在多种肿瘤中表达均有上调,与多种癌症具有明显的相关性;此外最新研究表明,NR2F6在肿瘤免疫方面同样具有重要功能,有望成为新型免疫调节靶点。文中就近年来国内外有关NR2F6的功能及其在肿瘤中的相关研究进行综述,以期为肿瘤治疗提供新思路。