Self-sacrificial template-induced modulation of conjugated microporous polymer microcapsules and shape-dependent enhanced photothermal efficiency for ablation of cancer cells

The one-step synthesis of nanoscale conjugated microporous polymer (NCMP) capsules is presented by using PMAA microspheres as self-sacrificial templates. Precise control over the morphology, nanostructure and shell thickness makes the NCMPs have a tunable NIR absorption ability and a shape-dependent photothermal conversion efficiency. Upon exposure to 808 nm light, they rapidly generate heat (NCMP concentration: 100 mu g mL(-1)) and cause thermal ablation of HeLa cells with less than 10% viability.

以聚甲基丙烯酸（PMAA）微球为自牺牲模板，介绍了纳米级共轭微孔聚合物（NCMP）胶囊的一步合成法。对其形态、纳米结构和壳层厚度的精确控制使得NCMP具有可调的近红外（NIR）吸收能力以及与形状相关的光热转换效率。在808nm光照射下，它们（NCMP浓度为100μg/mL）能迅速产生热量，并导致HeLa细胞热消融，细胞存活率低于10%。