Biomedical Application of Functional Materials in Organ-on-a-Chip

The organ-on-a-chip (OOC) technology has been utilized in a lot of biomedical fields such as fundamental physiological and pharmacological researches. Various materials have been introduced in OOC and can be broadly classified into inorganic, organic, and hybrid materials. Although PDMS continues to be the preferred material for laboratory research, materials for OOC are constantly evolving and progressing, and have promoted the development of OOC. This mini review provides a summary of the various type of materials for OOC systems, focusing on the progress of materials and related fabrication technologies within the last 5 years. The advantages and drawbacks of these materials in particular applications are discussed. In addition, future perspectives and challenges are also discussed.

器官芯片（OOC）技术已应用于许多生物医学领域，例如基础生理学和药理学研究。多种材料已被引入器官芯片中，大致可分为无机材料、有机材料和混合材料。尽管聚二甲基硅氧烷（PDMS）仍然是实验室研究的首选材料，但器官芯片所用材料在不断发展和进步，并推动了器官芯片的发展。这篇小型综述总结了器官芯片系统的各类材料，重点关注了过去5年材料及相关制造技术的进展。讨论了这些材料在特定应用中的优缺点。此外，还探讨了未来的前景和挑战。