Ruthenium-catalyzed aerobic oxidative coupling of alkynes with 2-aryl-substituted pyrroles

Ruthenium-catalyzed aerobic oxidative annulations of alkynes were accomplished with co-catalytic amounts of Cu(OAc)(2)center dot H2O under ambient air. The C-H/N-H bond functionalization occurred with unparalleled selectivities and ample scope to deliver structural analogs of bioactive marine alkaloids.

在环境空气下，使用催化量的Cu(OAc)₂·H₂O实现了钌催化的炔烃需氧氧化环化反应。C - H / N - H键的官能化反应具有独特的选择性和广泛的适用范围，可生成具有生物活性的海洋生物碱的结构类似物。