Effect of Periodontal Disease on Long-Term Outcomes After Percutaneous Coronary Intervention for De Novo Coronary Lesions in Non-Smokers

Background: This study aimed to investigate the effect of periodontal disease (PD) on the outcomes of patients with coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI). Methods and Results: The study included 77 consecutive non-smoking patients with de novo coronary lesions treated with a drug eluting stent (DES). Periodontal measurements, including the community periodontal index (CPI), were performed by independent periodontists. A CPI score of >= 3 was used to define PD. The occurrence of major adverse cardiac events (MACEs), which were defined as a composite of cardiovascular death, non-fatal myocardial infarction, target lesion revascularization, or non-target lesion revascularization, was compared between patients with and without PD. Of the 77 patients, 49 (63.6%) exhibited a CPI score of 3 or 4 and were assigned to the PD group. The remaining 28 patients (36.4%) were assigned to the non-PD group. Baseline clinical characteristics and angiographic findings were comparable between the 2 groups. MACEs occurred in 13 (26.5%) of the PD patients and 2 (7.1%) of the non-PD patients. Kaplan-Meier analysis showed a significantly lower MACE-free survival rate in the PD group than for the non-PD group (P=0.034). Conclusions: PD at baseline was associated with an increased risk of MACEs in CAD patients who were treated with a DES for de novo coronary lesions.

背景：本研究旨在探讨牙周病（PD）对经皮冠状动脉介入治疗（PCI）的冠状动脉疾病（CAD）患者预后的影响。 方法与结果：该研究纳入了77例连续的非吸烟且有新发冠状动脉病变并接受药物洗脱支架（DES）治疗的患者。由独立的牙周病医生进行牙周测量，包括社区牙周指数（CPI）。CPI评分≥3被用于定义牙周病。比较了有牙周病和无牙周病患者的主要不良心血管事件（MACE）的发生情况，MACE定义为心血管死亡、非致命性心肌梗死、靶病变血运重建或非靶病变血运重建的复合事件。在77例患者中，49例（63.6%）的CPI评分为3或4，并被归入牙周病组。其余28例患者（36.4%）被归入非牙周病组。两组的基线临床特征和血管造影结果具有可比性。牙周病患者中有13例（26.5%）发生MACE，非牙周病患者中有2例（7.1%）发生MACE。Kaplan - Meier分析显示，牙周病组无MACE生存率显著低于非牙周病组（P = 0.034）。 结论：基线时的牙周病与因新发冠状动脉病变接受DES治疗的CAD患者的MACE风险增加有关。