Familial influences on breast parenchymal patterns

Some studies accomplished thus far have indicated that mammographic patterns may serve as risk indices for breast cancer. The present investigation was undertaken to determine whether patterns are familial. Mammograms from 110 mothers and their daughters and 122 sister pairs and a like number of unrelated controls matched for patient age, reproductive history, and personal and family history of breast cancer and drawn from the files of the Radiology Department of Hutzel Hospital, Detroit, Michigan, were compared. A familial influence was indicated by the finding that pattern similarities were significantly stronger in test cases than in unrelated controls. This influence appeared to be manifested by premature age changes in daughters and younger sisters and consisted, primarily, of a decrease in DY and an increase in P2 patterns. The data suggest that performing mammography on first degree relatives of women with high risk P2 and DY patterns should be considered.

到目前为止完成的一些研究表明，乳房X线影像模式可作为乳腺癌的风险指标。本研究旨在确定这些模式是否具有家族性。对来自密歇根州底特律市赫策尔医院放射科档案中的110对母女、122对姐妹以及相同数量在患者年龄、生育史以及个人和家族乳腺癌病史方面匹配的无关对照者的乳房X线照片进行了比较。研究发现，在测试病例中模式相似性明显强于无关对照者，这表明存在家族影响。这种影响似乎表现为女儿和妹妹的年龄过早变化，主要包括DY模式减少和P2模式增加。数据表明，应该考虑对具有高风险P2和DY模式的女性的一级亲属进行乳房X线摄影检查。