Preparation of salbutamol imprinted magnetic nanoparticles via boronate affinity oriented surface imprinting for the selective analysis of trace salbutamol residues

Salbutamol (SAL) is one of the most widely abused feed additives in animal husbandry. Selective enrichment of SAL from complex biological samples is a key step for the analysis of SAL. Herein, we present SAL-imprinted magnetic nanoparticles (MNPs) as an ideal sorbent for selective enrichment of SAL. The SAL-imprinted MNPs were prepared according to the newly reported boronate affinity oriented surface imprinting. The prepared imprinted MNPs exhibited several significant advantages, such as excellent selectivity towards SAL, superb tolerance to interferences, fast binding equilibrium and easy manipulation, which made the obtained imprinted MNPs an ideal sorbent for selective enrichment. The feasibility of SAL-imprinted MNPs for real samples was well demonstrated by the analysis of trace SAL in pig liver. Because of their highly desirable properties, the SAL-imprinted MNPs could find more applications in the analysis of SAL.

沙丁胺醇（SAL）是畜牧业中滥用最广泛的饲料添加剂之一。从复杂生物样品中选择性富集SAL是分析SAL的关键步骤。在此，我们提出SAL印迹磁性纳米粒子（MNPs）作为一种用于SAL选择性富集的理想吸附剂。SAL印迹MNPs是根据新报道的硼酸亲和导向表面印迹法制备的。所制备的印迹MNPs具有几个显著优势，例如对SAL的优异选择性、对干扰的超强耐受性、快速的结合平衡以及易于操作，这使得所获得的印迹MNPs成为选择性富集的理想吸附剂。通过对猪肝中痕量SAL的分析，很好地证明了SAL印迹MNPs用于实际样品的可行性。由于其非常理想的性能，SAL印迹MNPs可在SAL分析中找到更多应用。