Mitochondria are essential organelles in cells not only because they supply over 90% of the cell's energy but also because their dysfunction is associated with disease. Owing to the importance of mitochondria, there are many questions about mitochondria that must be answered. Cytoplasmic male sterility (CMS) is a mysterious natural phenomenon, and the mechanism of the origin of CMS is unknown. Despite successful utilization of CMS and restoration of fertility (Rf) in practice, the underlying mechanisms of these processes remain elusive. This review summarizes the genes involved in CMS and Rf, with a special focus on recent studies reporting the mechanisms of the CMS and Rf pathways, and concludes with potential working models. (C) 2014 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
线粒体是细胞中必不可少的细胞器,不仅因为它们提供细胞90%以上的能量,还因为其功能障碍与疾病相关。由于线粒体的重要性,有许多关于线粒体的问题必须得到解答。细胞质雄性不育(CMS)是一种神秘的自然现象,CMS的起源机制尚不清楚。尽管在实践中CMS已得到成功利用以及育性恢复(Rf)得以实现,但这些过程的潜在机制仍然难以捉摸。这篇综述总结了参与CMS和Rf的基因,特别关注近期报道CMS和Rf途径机制的研究,并以潜在的工作模型作为结论。(C)2014爱思唯尔公司和线粒体研究学会。保留所有权利。