Association Between the Number of Remaining Teeth and Body Mass Index in Japanese Inpatients with Schizophrenia.

There is little evidence regarding the effects of dental status on body mass index (BMI) in inpatients with schizophrenia. Thus, we performed a cross-sectional study to explore the associations between the number of remaining teeth and BMI in Japanese inpatients with schizophrenia. We performed multiple regression analysis to assess the effects of potential predictors (age, sex, number of remaining teeth, number of antipsychotics prescribed, chlorpromazine equivalent dose, and antipsychotic type) on BMI in 212 inpatients with schizophrenia. We then compared the number of remaining teeth between inpatients with schizophrenia and the Japanese general population (3283 individuals) from the Japan Dental Diseases Survey 2016, using an analysis of covariance with age and sex as covariates. Multiple regression analysis showed that the number of remaining teeth and the number of antipsychotics prescribed were significantly correlated with BMI (standardized regression coefficient = 0.201 and 0.235, respectively). In the analysis of covariance, inpatients with schizophrenia had significantly fewer remaining teeth compared with the Japanese general population (mean 14.8 [standard deviation: 10.9] vs mean 23.0 [standard deviation: 8.1]). These results suggested that tooth loss and antipsychotic polypharmacy affect BMI in inpatients with schizophrenia, and that inpatients with schizophrenia lose more teeth compared with the general population.

关于精神分裂症住院患者的牙齿状况对体重指数（BMI）的影响，证据甚少。因此，我们进行了一项横断面研究，以探究日本精神分裂症住院患者剩余牙齿数量与BMI之间的关联。 我们进行了多元回归分析，以评估潜在预测因素（年龄、性别、剩余牙齿数量、开具的抗精神病药物数量、氯丙嗪等效剂量以及抗精神病药物类型）对212名精神分裂症住院患者BMI的影响。然后，我们以年龄和性别作为协变量，通过协方差分析比较了精神分裂症住院患者和来自2016年日本牙科疾病调查的日本普通人群（3283人）的剩余牙齿数量。 多元回归分析显示，剩余牙齿数量和开具的抗精神病药物数量与BMI显著相关（标准化回归系数分别为0.201和0.235）。在协方差分析中，与日本普通人群相比，精神分裂症住院患者的剩余牙齿明显更少（均值为14.8[标准差：10.9]对比均值为23.0[标准差：8.1]）。 这些结果表明，牙齿缺失和抗精神病药物的多重用药会影响精神分裂症住院患者的BMI，并且与普通人群相比，精神分裂症住院患者牙齿缺失更多。