SNAP23 promotes the malignant process of ovarian cancer.

Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. Here, we identified SNAP23, a member of SNARE complex, as a potential oncogene in OC. We determined the expression of SNAP23 in OC tissues and explored the clinical significance through bioinformatics analysis. The effects of SNAP23 on OC cell proliferation, migration, invasion, cell cycle and apoptosis were then evaluated in vitro. SNAP23 is hyper-expressed in OC tumor tissues compared to normal tissues, and increased expression of SNAP23 is associated with a poor progression free survival (HR = 1.24, 95% CI = 1.07–1.44, p = 0.0042). SNAP23 knock down increases cell apoptosis and inhibits cell proliferation, migration and invasion of OC cells. GO analysis reveals that most genes correlated highly with SNAP23 were enriched in metabolic process. Our data suggest that SNAP23 may serve as an oncogene promoting tumorigenicity of OC cells by decreasing apoptotic process.

卵巢癌（OC）是主要的妇科恶性肿瘤，SNARE蛋白与肿瘤进展密切相关。在此，我们确定SNARE复合物的成员SNAP23是卵巢癌中一种潜在的癌基因。 我们测定了SNAP23在卵巢癌组织中的表达，并通过生物信息学分析探讨了其临床意义。然后在体外评估了SNAP23对卵巢癌细胞增殖、迁移、侵袭、细胞周期和凋亡的影响。 与正常组织相比，SNAP23在卵巢癌肿瘤组织中高表达，并且SNAP23表达增加与无进展生存期差相关（风险比 = 1.24，95%置信区间 = 1.07 - 1.44，p = 0.0042）。敲低SNAP23可增加细胞凋亡，并抑制卵巢癌细胞的增殖、迁移和侵袭。基因本体论（GO）分析显示，大多数与SNAP23高度相关的基因富集在代谢过程中。 我们的数据表明，SNAP23可能作为一种癌基因，通过减少凋亡过程来促进卵巢癌细胞的致瘤性。