hUCMSCs Mitigate LPS-Induced Trained Immunity in Ischemic Stroke.

Innate immune memory is a part of the innate immune system that facilitates the elimination of pathogens. However, it may exacerbate neuropathology. In this study, we found that innate immune memory is detrimental in stroke, because it promotes the acute immune response and exacerbates ischemic infarcts. Mesenchymal stem cell therapy has been widely studied for its therapeutic potential in various diseases including stroke, but whether it diminishes innate immune memory has not been studied. Here, our study demonstrates that, after the activation of innate immune memory by lipopolysaccharide, mesenchymal stem cell therapy can diminish innate immune memory though down-regulation of H3 methylation and subsequently protect against stroke. Our results demonstrate that innate immune memory is detrimental in stroke, and we describe a novel potential therapeutic target involving the use of mesenchymal stem cells to treat stroke patients.

先天性免疫记忆是先天性免疫系统的一部分，有助于病原体的清除。然而，它可能会加重神经病理学症状。在这项研究中，我们发现先天性免疫记忆在中风中是有害的，因为它会促进急性免疫反应并加重缺血性梗死。间充质干细胞疗法因其在包括中风在内的多种疾病中的治疗潜力而被广泛研究，但是它是否会减弱先天性免疫记忆尚未被研究。在此，我们的研究表明，在脂多糖激活先天性免疫记忆之后，间充质干细胞疗法可以通过下调H3甲基化来减弱先天性免疫记忆，进而预防中风。我们的研究结果表明先天性免疫记忆在中风中是有害的，并且我们描述了一个新的潜在治疗靶点，涉及使用间充质干细胞来治疗中风患者。