儿茶酚胺检测技术的研究进展

Catecholamines (CAs) are a class of biogenic compounds that play important physiological roles as neurotransmitters and hormones in humans and animals. They are important markers for diagnosing diseases and dysfunctions and are also components of sympathomimetic drug formulations. Therefore, the determination methods of CAs in biological samples and living cells, as well as their accuracy, sensitivity, selectivity and real - time performance, are of great significance for the diagnosis of diseases and the study of pathophysiological mechanisms. This article reviews the detection methods of CAs in the past five years from different levels such as clinical biological samples, living cells and living bodies, and describes the performance characteristics and applications of detection methods including fluorescence imaging, electrochemistry, mass spectrometry, photometric analysis, non - invasive imaging techniques, etc.

儿茶酚胺（catecholamines,CAs）是一类生物源性化合物,它们作为神经递质和激素在人和动物体内发挥着重要的生理作用。它们是诊断疾病和功能障碍的重要标志物,也是拟交感神经药物制剂的成分。因此生物样品、活细胞中CAs的测定方法,以及它们的精确度、灵敏度、选择性及实时性,对疾病的诊断及病理生理机制的研究具有重要意义。本文从临床生物样品、活体细胞、活体等不同层次综述近5年来CAs的检测方法,描述包括荧光成像法、电化学法、质谱法、光度分析法、非损伤成像技术等检测方法的性能特征及应用。