New directions for the clathrin adaptor AP-1 in cell biology and human disease.

The clathrin adaptor protein complex-1 (AP-1) is a central player in cell physiology and human health. It is best known for its role in linking clathrin to its cargo at the trans-Golgi network and endosomes. It participates in traffic important for the correct function of a large number of organelles, including the trans-Golgi network, endosomes, lysosomes, lysosome-related organelles, and plasma membrane. Although it was one of the first clathrin adaptors identified, new discoveries about cargo and pathways that depend on AP-1 continue to emerge. This review summarizes new research into AP-1 that further illuminates its roles in the traffic of plasma membrane proteins, in maintaining TGN content, and in human disease.

网格蛋白衔接蛋白复合物 -1（AP -1）是细胞生理学和人类健康的核心参与者。它最为人所知的作用是在反式高尔基体网络和内体中使网格蛋白与其货物相连。它参与对大量细胞器（包括反式高尔基体网络、内体、溶酶体、溶酶体相关细胞器和质膜）的正确功能至关重要的运输过程。尽管它是最早被发现的网格蛋白衔接蛋白之一，但关于依赖AP -1的货物和通路的新发现仍不断涌现。这篇综述总结了对AP -1的新研究，这些研究进一步阐明了它在质膜蛋白运输、维持反式高尔基体网络内容物以及在人类疾病中的作用。