Characterization of nanoparticle distribution in microcirculation: The influence of blood cells and vascular geometry

This paper focuses on characterization of nanoparticle (NP) distribution in microcirculation. In microcirculation, the vessel size is comparable to the size of red blood cells (RBCs) and the existence of blood cells largely influences the dispersion and binding distribution of NPs. The branching geometry of these vessels leads to non-uniform binding distribution of particles. The influence of various effects such as blood cells, vessel geometry, and shear rates on NP delivery are characterized. The RBCs are found to enhance the binding of NPs at all shear rates while reduces the binding of microparticles at low shear rates. The branching geometry of the capillary vessels leads to higher particle binding density.

本文重点研究微循环中纳米颗粒（NP）分布的特性。在微循环中，血管尺寸与红细胞（RBC）大小相当，血细胞的存在在很大程度上影响纳米颗粒的分散和结合分布。这些血管的分支几何结构导致颗粒的结合分布不均匀。对血细胞、血管几何结构和剪切速率等各种因素对纳米颗粒递送的影响进行了表征。研究发现，在所有剪切速率下，红细胞都能增强纳米颗粒的结合，而在低剪切速率下则会降低微粒的结合。毛细血管的分支几何结构导致更高的颗粒结合密度。