Design of novel polymer-supported chiral catalyst for asymmetric transfer hydrogenation in water

New polymer-supported chiral sulfonamides containing sulfonated pendant group have been synthesized. Chiral catalyst prepared from the new polymer-support is more effective for asymmetric transfer hydrogenation of aromatic ketones in water compared to that prepared from conventional polystyrene-support. Polymer-supported catalysts containing quaternary ammonium salt as a pendant increased not only the reactivity but also the enantioselectivity in asymmetric transfer hydrogenation in water. Moreover, this type of polymer can be reused without loss of the catalytic activity. (c) 2006 Elsevier Ltd. All rights reserved.

合成了含有磺化侧基的新型聚合物负载的手性磺酰胺。与由常规聚苯乙烯负载体制备的手性催化剂相比，由这种新型聚合物负载体制备的手性催化剂在水中对芳香酮的不对称转移氢化反应更有效。含有季铵盐作为侧基的聚合物负载催化剂不仅提高了在水中不对称转移氢化反应的反应活性，还提高了对映选择性。此外，这种类型的聚合物可以重复使用而不会损失催化活性。（c）2006爱思唯尔有限公司。保留所有权利。