Sleep duration as a risk factor for the development of type 2 diabetes or impaired glucose tolerance: Analyses of the Quebec Family Study

Objective: To examine the long-term relationship between sleep duration and type 2 diabetes or impaired glucose tolerance (IGT).Methods: Body composition measurements and self-reported sleep duration were determined in a longitudinal sample of 276 individuals aged 21 to 64 years followed for a mean of 6 years. Risk factors of type 2 diabetes/IGT over the follow-up were determined and relative risks (RRs) calculated for the development of type 2 diabetes/IGT by sleep duration group.Results: Independent risk factors of type 2 diabetes/IGT over the follow-up included age, obesity, sleep duration, and glucose/insulin homeostasis indicators. Using adults with 7-8 h of sleep as a reference, the adjusted RR for the development of type 2 diabetes/IGT was 2.78 (1.61-4.12) for those with = 9 h of sleep. These elevated RRs remained significant after adjustment for body mass index, waist circumference or percent body fat.Conclusion: Short and long sleeping times are associated with a higher risk of developing type 2 diabetes/IGT, independent of several covariates. These results suggest that sleep duration may represent a novel risk factor for type 2 diabetes/IGT. (C) 2009 Elsevier B.V. All rights reserved.

目的：研究睡眠时间与2型糖尿病或糖耐量受损（IGT）之间的长期关系。 方法：对276名年龄在21至64岁的个体进行纵向样本研究，平均随访6年，测定身体成分并收集自我报告的睡眠时间。确定随访期间2型糖尿病/IGT的危险因素，并按睡眠时间分组计算发生2型糖尿病/IGT的相对风险（RRs）。 结果：随访期间2型糖尿病/IGT的独立危险因素包括年龄、肥胖、睡眠时间以及血糖/胰岛素内稳态指标。以睡眠时间为7 - 8小时的成年人作为参照，睡眠时间≥9小时的人发生2型糖尿病/IGT的校正RR为2.78（1.61 - 4.12）。在对体重指数、腰围或体脂百分比进行校正后，这些升高的RR仍然显著。 结论：睡眠时间过短和过长都与发生2型糖尿病/IGT的较高风险相关，且与多种协变量无关。这些结果表明睡眠时间可能是2型糖尿病/IGT的一个新的危险因素。（C）2009爱思唯尔B.V. 版权所有