Deformable image registration for defining the postimplant seroma in permanent breast seed implant brachytherapy

PURPOSE: To demonstrate the benefit of deformable image registration (DIR) to define postimplant seromas in permanent breast seed implants (PBSIs) by adapting preimplant seromas to postimplant images.METHODS AND MATERIALS: Planning and Day 0 CT scans from 15 consecutive PBSI. patients were included. Seromas were contoured on the preimplant CTs. After implant, DIR (MIM Maestro; MIM Software, Inc., Cleveland, OH) was used to adapt preimplant seromas to postimplant scans. Resulting seromas were evaluated for accuracy and adjusted if required, and pre- and postimplant seroma volumes were recorded and compared. DIR. was validated by assessing the spatial correspondence of surgical clips pre- and postimplant in eight cases. Retrospectively, rigid registration was also investigated.RESULTS: Surgical clip location corresponded between pre- and postimplant images with a median. agreement of

目的：通过将植入前血清肿适配到植入后图像，展示可变形图像配准（DIR）在确定永久性乳腺粒子植入（PBSI）后植入血清肿方面的优势。 方法和材料：纳入15例连续PBSI患者的计划CT和第0天CT扫描。在植入前CT上勾勒出血清肿轮廓。植入后，使用DIR（MIM Maestro；MIM软件公司，俄亥俄州克利夫兰市）将植入前血清肿适配到植入后扫描图像。对所得血清肿进行准确性评估，必要时进行调整，并记录和比较植入前和植入后血清肿体积。通过评估8例患者植入前和植入后手术夹的空间对应性来验证DIR。回顾性地，也对刚性配准进行了研究。 结果：手术夹位置在植入前和植入后图像之间具有中位一致性。