The Role of AMPK in Mitochondria Quality Control

Mitochondria are one of the important intracellular organelles in mammals that maintain mitochondria quality by regulating mitochondria biogenesis, fusion/fission and mitophagy processes. However, mitochondrial dysfunction will lead to the occurrence of various diseases. AMPK (AMP-activated protein kinase) is a key sensor of cellular energy status that is activated in response to energy stress, and regulates mitochondrial function, thereby affecting cell energy metabolism and health of organisms, suggesting that AMPK is an important regulator of mitochondrial quality. Hence, this review focuses on the structure and activation of AMPK, and its roles in the control of mitochondria quality in mammal cells, which may provide reference for modulating mitochondria quality by activating AMPK, thereby maintaining health of organisms and reducing disease incidence.

线粒体是哺乳动物细胞内重要的细胞器之一，通过调节线粒体生物发生、融合/分裂以及线粒体自噬过程来维持线粒体质量。然而，线粒体功能障碍会导致多种疾病的发生。AMPK（腺苷酸活化蛋白激酶）是细胞能量状态的关键感受器，在能量应激时被激活，并调节线粒体功能，进而影响细胞能量代谢和生物体健康，这表明AMPK是线粒体质量的重要调节因子。因此，本综述聚焦于AMPK的结构与激活，及其在调控哺乳动物细胞线粒体质量中的作用，这可能为通过激活AMPK来调节线粒体质量，从而维持生物体健康并降低疾病发生率提供参考。