组蛋白甲基化与糖尿病心肌病

Histone methylation is a very crucial post-translational modification and plays an important role in various heart diseases including diabetic cardiomyopathy. A large amount of evidence shows that histone methylation modification is closely related to hyperglycemia, insulin resistance, lipid and advanced glycation end product deposition, inflammatory immunity and oxidative stress, endoplasmic reticulum stress, autophagy and apoptosis, etc., and these pathological factors play an important role in the pathogenesis of diabetic cardiomyopathy. This article conducts a detailed discussion and elaboration on the histone methylation modification and the pathogenesis of diabetic cardiomyopathy, hoping to provide new theoretical basis and targets for the treatment of diabetic cardiomyopathy from the perspective of epigenetics.

组蛋白甲基化是一种非常关键的翻译后修饰,在包括糖尿病心肌病在内的各种心脏病中发挥着重要作用。大量的证据显示,组蛋白甲基化修饰与高糖血症、胰岛素抵抗、脂质与晚期糖基化终末产物沉积、炎症免疫和氧化应激、内质网应激、自噬与细胞凋亡等密切相关,而这些病理因素在糖尿心肌病的发病进程中扮演着重要的角色。本文就组蛋白甲基化修饰与糖尿心肌病发病机制进行详细的探讨和阐述,以期从表观遗传学角度为糖尿病心肌病的治疗提供新的理论依据和靶点。