A simple and highly diasteroselective approach for the vicinal dichlorination of functional olefins

Organocatalytic stereospecific vicinal dicholorination of a wide variety of functionalized olefins such as ketoesters, esters, ketones, carvone,.cholesterol and ethyl sorbate (27 examples) was achieved using inexpensive sulfuryl chloride as well as a simple phosphine catalyst.under mild reaction conditions. The products were obtained with good to excellent yields and diastereoselectivities (up to 96% yield and.>25 : 1 dr).

在温和的反应条件下，使用廉价的磺酰氯以及一种简单的膦催化剂，实现了对多种官能化烯烃（如酮酯、酯、酮、香芹酮、胆固醇和山梨酸乙酯，共27个实例）的有机催化立体专一性邻位二氯化反应。产物以良好至优异的产率和非对映选择性获得（产率高达96%，非对映选择性>25:1）。