Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor.

Organic electrochemistry has emerged as an enabling and sustainable technology in modern organic synthesis. Despite the recent renaissance of electrosynthesis, the broad adoption of electrochemistry in the synthetic community, and especially in industrial settings, has been hindered by the lack of general, standardized platforms for high-throughput experimentation (HTE). Herein, we disclose the design of the HTe–Chem, a high-throughput microscale electrochemical reactor that is compatible with existing HTE infrastructure and enables the rapid evaluation of a broad array of electrochemical reaction parameters. Utilizing the HTe–Chem to accelerate reaction optimization, reaction discovery, and chemical library synthesis is illustrated using a suite of oxidative and reductive transformations under constant current, constant voltage, and electrophotochemical conditions. Electrochemistry is an enabling technology in modern organic synthesis. The HTe−Chem is an HTE reactor that accelerates the discovery, optimization, and application of electrochemical reactions.

有机电化学已成为现代有机合成中一种赋能且可持续的技术。尽管电合成最近再度兴起，但在合成领域，尤其是工业环境中，电化学的广泛应用因缺乏用于高通量实验（HTE）的通用标准化平台而受阻。在此，我们介绍了HTe - Chem的设计，这是一种高通量微型电化学反应器，它与现有的HTE基础设施兼容，能够快速评估广泛的电化学反应参数。通过在恒流、恒压和光电化学条件下的一系列氧化和还原转化反应，说明了利用HTe - Chem加速反应优化、反应发现和化学库合成。 电化学是现代有机合成中的一种赋能技术。HTe - Chem是一种高通量实验反应器，可加速电化学反应的发现、优化和应用。