Weight loss does not decrease risk of breast cancer-related arm lymphedema.

The goal of this study was to determine the relationship between postoperative weight change and breast cancer-related lymphedema. In this cohort study, 1,161 women underwent unilateral breast surgery for breast cancer from 2005 to 2020 and were prospectively screened for breast cancer-related lymphedema. Arm volume measurements were obtained via an optoelectronic perometer preoperatively, postoperatively, and in the follow-up setting every 6–12 months. Mean follow-up from preoperative baseline was 49.1 months. The main outcome was breast cancer-related lymphedema, defined as a relative volume change of the ipsilateral arm of ≥10% at least 3 months after surgery. 92 patients (7.9%) developed breast cancer-related lymphedema. Net weight loss vs. net weight gain from baseline to last follow-up was not protective against developing BCRL (HR 1.38; 95% CI 0.89 – 2.13; p=0.152). Although weight loss may be recommended as part of an individualized lifestyle management program for overall health, weight loss alone may not decrease the risk of developing BCRL. Weight loss, when compared to weight gain, does not decrease the risk of BCRL (HR 1.38; 95% CI 0.89 – 2.13; p=0.152).

本研究的目的是确定术后体重变化与乳腺癌相关淋巴水肿之间的关系。 在这项队列研究中，2005年至2020年期间，1161名女性因乳腺癌接受了单侧乳房手术，并对乳腺癌相关淋巴水肿进行了前瞻性筛查。术前、术后以及随访期间每6 - 12个月通过光电周长测量仪获取手臂体积测量值。从术前基线开始的平均随访时间为49.1个月。主要观察结果是乳腺癌相关淋巴水肿，其定义为术后至少3个月患侧手臂相对体积变化≥10%。 92名患者（7.9%）发生了乳腺癌相关淋巴水肿。从基线到最后一次随访的净体重减轻与净体重增加相比，对发生乳腺癌相关淋巴水肿没有保护作用（风险比1.38；95%置信区间0.89 - 2.13；p = 0.152）。 尽管作为个体化生活方式管理方案的一部分，可能会建议为了整体健康而减轻体重，但仅减轻体重可能不会降低发生乳腺癌相关淋巴水肿的风险。 与体重增加相比，体重减轻不会降低乳腺癌相关淋巴水肿的风险（风险比1.38；95%置信区间0.89 - 2.13；p = 0.152）